Ayahuasca Vine: Exploring its Properties and Impact on the Brain

Ayahuasca Vine: Exploring its Properties and Impact on the Brain


Over the past decade, the ayahuasca drink has gained popularity in the Western world. As people seek alternative solutions to widespread health issues like depression and anxiety, conventional medicine often falls short in providing long-term relief. The use of ayahuasca has emerged as a popular choice for those looking for spiritual exploration and connection with the divine. This article delves into the properties and effects of the ayahuasca vine on the brain, shedding light on its significance in the context of psychedelic culture.

The Ayahuasca Drink and its Components

The ayahuasca drink is prepared by combining two plants from the Amazon region: Banisteriopsis caapi (ayahuasca or yagé) and Psychotria viridis (chacruna or chacrona). While the liana Banisteriopsis caapi has been traditionally revered as the master plant in Amazonian traditional medicine, other sources of DMT from plants like chapilonga and jurema can also be added to the mixture. Interestingly, regardless of the additional ingredients, the ayahuasca liana remains a fundamental component in the preparation process.

Understanding Ayahuasca’s Healing Effects

Early on, it was believed that ayahuasca’s healing effects were solely attributed to DMT, the primary psychoactive compound found in the Psychotria viridis plant. DMT is known to produce the distinctive visionary psychedelic effects associated with ayahuasca. However, the body rapidly breaks down DMT due to the action of the MAO-A enzyme. Further research revealed that Banisteriopsis caapi inhibits the action of MAO-A through B-carbolines, which possess reversible and A-selective monoamine oxidase inhibitory properties. This inhibition allows DMT to remain active in the brain for longer periods, resulting in intensified and prolonged psychedelic effects.

Beyond DMT: Therapeutic Properties of B-carbolines

While DMT plays a significant role, subsequent investigations have demonstrated that the B-carbolines present in the Banisteriopsis caapi liana possess important therapeutic properties independent of DMT. These compounds contribute significantly to the curative effects of ayahuasca. Therefore, the healing potential of ayahuasca extends beyond its DMT content, making it a comprehensive medicinal concoction according to studies conducted by Morales García et al. (2017) and dos Santos, R. & Jaime EC Hallak, J. (2017).

Microdosing Ayahuasca

In recent years, psychedelic microdosing has gained popularity due to its reported health benefits. Microdosing involves taking small subperceptive doses of psychedelics over an extended period. When it comes to ayahuasca, microdosing aims to attain psychological improvements and initiate a transformative process while maintaining one’s daily routine and responsibilities. By consuming minuscule amounts of the caapi extract, which contains negligible levels of DMT, individuals can experience the benefits offered by ayahuasca without inducing full psychedelic experiences or visions.

Properties and Effects on the Brain of the Liana Banisteriosis Caapi

Next, we will explore the properties and effects of the liana Banisteriosis caapi on the human brain. Banisteriosis caapi is known for its psychoactive alkaloids, including harmine, tetrahydroharmine, and harmaline, which can have significant impacts on perception, mood, and cognition.

Harmine: A Beneficial Substance for the Brain

Harmine, the primary β-carboline found in ayahuasca, has been the subject of scientific studies that highlight its positive effects on the human brain. Researchers have discovered that harmine possesses anti-inflammatory, neuroprotective, and memory-stimulating properties (dos Santos, R. & Jaime EC Hallak, J.2017).

Anti-inflammatory Effects and Neuroprotection

Harmine’s anti-inflammatory effects are particularly noteworthy. It works by inhibiting the production of specific inflammatory molecules, thereby reducing the overall inflammatory response in the body. Furthermore, harmine has been found to safeguard brain cells against damage caused by toxins and other stressors. These findings suggest that harmine could potentially be used in the prevention and treatment of neurodegenerative diseases like Parkinson’s and Alzheimer’s (Serrano-Dueñas et al., 2001).

Neuroprotective Effects and Brain Cell Growth

Studies conducted on cultured hippocampal cells and animal models have revealed additional neuroprotective effects of harmine. It has been associated with reduced excitotoxicity, inflammation, and oxidative stress. Furthermore, harmine has shown the ability to increase the levels of brain-derived neurotrophic factor (BDNF), a protein crucial for nerve cell growth and survival (Dos Santos, R. & Jaime EC Hallak, J.2017).

Harmine’s Impact on Memory

Harmine has also demonstrated its potential in enhancing memory. Research conducted by Morales-Garcia and colleagues showed that harmine significantly increased the production of new brain cells in the hippocampus, a region critical for memory. This suggests that harmine could be beneficial in the treatment of memory-related conditions such as dementia and Alzheimer’s (Morales-Garcia et al., 2017).

Progenitor Cell Proliferation and Memory Consolidation

Studies investigating the effects of alkaloids in ayahuasca on progenitor cell proliferation in the hippocampus have found promising results. Harmine and harmaline, in particular, were found to significantly stimulate the proliferation of progenitor cells (Oliveira, AM, et al., 2010). Another study focused on harmine’s impact on memory consolidation in mice, revealing that its administration notably improved long-term memory. This suggests that harmine could be an effective treatment option for neurodegenerative diseases affecting memory (Meyer, BJ et al., 2015).

Harmaline: Anxiolytic and Antidepressant Effects

Harmaline, another alkaloid present in Banisteriosis caapi, possesses monoamine oxidase inhibitor (MAOI) properties. This means that it can increase the levels of serotonin, dopamine, and norepinephrine in the brain, which are associated with mood regulation, cognition, and the stress response.

Studies conducted on rats have investigated the anxiolytic and antidepressant effects of harmaline. The results showed that harmaline administration significantly improved anxiety and depression-related behaviors. Researchers also observed effects on electroencephalographic activity, indicating that harmaline’s ability to elevate serotonin and norepinephrine levels in the brain might be responsible for these effects (Sabuncuoglu, S., et al. 2018 ; Sadiq, S. et al. 2018).

Properties and Effects on the Brain of the Liana Banisteriosis Caapi

Ayahuasca’s Impact on the Default Neural Network (DNN)

Ayahuasca, a psychoactive brew made from the liana Banisteriosis caapi, has been the subject of scientific studies examining its effects on the brain’s default neural network (DNN) and changes in brain connectivity. These studies shed light on the potential benefits and alterations that occur within the brain.

Expansion of Local Neural Network and Decreased Brain Connectivity

Palhano-Fontes et al. (2015) conducted a study using functional magnetic resonance imaging (fMRI) to explore the effects of ayahuasca on the default neural network of healthy individuals. Their findings revealed significant changes in both activity and connectivity within the default neural network following ayahuasca administration. These changes indicated an expansion of the local neural network and a decrease in overall brain connectivity. It is worth noting that an overactive default neural network has been associated with depression, and alterations in the network could be linked to other mental conditions, such as Alzheimer’s.

Anatomical Changes in the Cingulate Cortex and Personality Traits

Bouso et al. (2015) investigated the effects of chronic ayahuasca use on brain structure and personality. The study focused on individuals who had consumed ayahuasca regularly over a long period. The researchers observed anatomical changes in the cingulate cortex, a vital region of the default neural network, among chronic ayahuasca users. Notably, these structural changes were accompanied by alterations in personality, including increased openness to experience and enhanced creativity.

Insights from Neuroimaging Research

Advancements in neuroimaging research have further contributed to our understanding of the neurobiological mechanisms of ayahuasca. Recent studies have selectively examined neuroimaging results related to human consumption of ayahuasca. Santos et al. (2023) found that local neural networks appeared to expand while overall brain connectivity decreased. Additionally, chronic users exhibited anatomical changes, particularly in relation to the cingulate cortex.

Antidepressant Effects of Ayahuasca

Research has also explored the antidepressant effects of ayahuasca, particularly in patients with recurrent depression. Studies conducted by Palhano Fortes et al. (2019) and Osório et al. (2015) revealed that a single dose of ayahuasca led to a significant improvement in depressive symptoms within 24 hours, as measured by the Hamilton Depression Scale. Moreover, increased blood perfusion was observed in the medial prefrontal area, which is associated with emotional regulation and decision making. The evidence suggests that ayahuasca may have rapid-acting antidepressant properties.


As interest in alternative medicine continues to grow, the ayahuasca drink has captured the attention of many in the Western world. Rooted in spiritual exploration, this traditional Amazonian brew has found its place in the resurgence of psychedelic culture. By understanding its properties and effects on the brain, we gain insights into the therapeutic potential of ayahuasca beyond its primary psychoactive compound, DMT. Whether used in traditional ceremonies or explored through microdosing, the ayahuasca vine offers a unique and profound journey of self-discovery and healing.

Reference bibliography:

  1. Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies, Journal of Psychoactive Drugs, 49: 1, 1-10, DOI: 10.1080/02791072.2016.1260189
  2. Sabuncuoglu, S., Uzbay, T., & Kayir, H. (2018). Anxiolytic and antidepressant effects of harmaline in rats: A behavioral and electroencephalographic study. Pharmacology, Biochemistry and Behavior, 168, 44-50. doi: 10.1016/j.pbb.2018.04.008
  3. Sadiq, SA, Hassan, AS, Khan, RA, Zaidi, SM, Anwar, F., & Tahir, M. (2018). Antidepressant-like activity of harmaline and its possible mechanism of action in mice. Journal of Ethnopharmacology, 212, 38-47. doi: 10.1016/j.jep.2017.10.008
  4. Santos GHdM, Rodrigues LS, Rocha JM, Rossi GN, Ona G, Bouso JC, Hallak JEC, dos Santos RG. Neural Network Modulation of Ayahuasca: A Systematic Review of Human Studies. Psychoactives. 2023; 2(1):76-91. https://doi.org/10.3390/psychoactives2010006
  5. Serrano-Duenas, et al. (2001). Effects of Banisteriopsis caapi extract on Parkison’s disease. Scientific Review of Alternative Medicines, 5(3), p. 127-132.
  6. Souza, RR, Zanelati, TV, Guimarães, FS, & Del Bel, EA (2015). Harmine, a beta-carboline alkaloid, enhances memory consolidation in mice. Behavioral Brain Research, 292, 25-34. doi: 10.1016/j.bbr.2015.05.027

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